550 research outputs found

    Domestic heat pumps in the UK: user behaviour, satisfaction and performance

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    Consumer adoption of microgeneration technologies is part of the UK strategy to reduce carbon emissions from buildings. Domestic heat pumps are viewed as a potentially important carbon saving technology, given the ongoing decarbonisation of the electricity supply system. To address the lack of independent evaluation of heat pump performance, the Energy Saving Trust undertook the UK’s first large-scale heat pump field trial, which monitored 83 systems in real installations. As part of the trial, the Open University studied the consumers’ experience of using a domestic heat pump. An in-depth user survey investigated the characteristics, behaviour, and satisfactions of private householders and social housing residents using ground source and air source heat pumps for space and/or water heating, and examined the influence of user-related factors on measured heat pump system efficiency. The surveys found that most users were satisfied with the reliability, heating, hot water, warmth and comfort provided by their system. Analysis of user characteristics showed that higher system efficiencies were associated with greater user understanding of their heat pump system, and more continuous heat pump operation, although larger samples are needed for robust statistical confirmation. The analysis also found that the more efficient systems in the sample were more frequently located in the private dwellings than at the social housing sites and this difference was significant. This is explained by the interaction between differences in the systems, dwellings and users at the private and social housing sites. The implications for heat pump research, practice and policy are discussed

    Osteoporosis Epidemiology Among Adults With Cerebral Palsy: Findings From Private and Public Administrative Claims Data

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    Individuals with cerebral palsy (CP) have an increased risk for the early development of osteoporosis; however, little is known about the epidemiology of osteoporosis for adults with CP, which is vital to inform clinical practice for osteoporosis prevention, treatment, and management. The purpose of this cross‐sectional study was to determine sex‐stratified prevalence of osteoporosis among adults with CP, as compared with adults without CP. Data from 2016 were extracted from Optum Clinformatics Data Mart (private insurance administrative claims data) and a random 20% sample from the fee‐for‐service Medicare (public insurance administrative claims data). Diagnostic codes were used to identify CP and osteoporosis diagnoses. Sex‐stratified prevalence of osteoporosis was compared between adults with and without CP for the following age groups: 18 to 30, 31 to 40, 41 to 50, 51 to 60, 61 to 70, and >70 years of age. The overall prevalence of osteoporosis was 4.8% for adults without CP (n = 8.7 million), 8.4% for privately insured adults with CP (n = 7,348), and 14.3% for publicly insured adults with CP (n = 21,907). Women and men with CP had a higher prevalence of osteoporosis compared with women and men without CP for all age groups. Finally, publicly insured women and men with CP had a higher prevalence of osteoporosis compared with privately insured women and men with CP for all age groups, except for the similar prevalence among the 18‐ to 30‐year age group. These findings suggest that osteoporosis is more prevalent among adults with CP compared with adults without CP. Study findings highlight the need for earlier screening and preventive medical services for osteoporosis management among adults with CP. © 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral ResearchPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/152612/1/jbm410231_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/152612/2/jbm410231.pd

    User-centred improvements to energy efficiency products and renewable energy systems: research on household adoption and use

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    The development and rapid consumer adoption of energy efficiency products and renewable energy systems are key elements of the UK and the EU carbon reduction strategies to meet the challenge of climate change. Many such technologies are available for domestic use, but despite government incentives to meet carbon reduction targets consumer adoption has been slow. This Open University research with 111 in-depth interviews plus an on-line survey with nearly 400 responses, investigates consumer adoption, non-adoption and use of these technologies. Results show that it is important to research consumer use experiences, problems and requirements when designing and developing “green” technologies. With results tailored to each technology, this study shows that user-centred improvements are required to improve functionality, ergonomics, inter-connectedness with other systems and symbolic value, and to reduce cost and payback. User-centred research supports new product/system design and development to promote more rapid adoption and carbon-saving use of energy efficient and renewable technologies in homes

    Low Dose of Bisphosphonate Enhances Sclerostin Antibody‐Induced Trabecular Bone Mass Gains in Brtl/+ Osteogenesis Imperfecta Mouse Model

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    Osteogenesis imperfecta (OI) is a genetic disorder characterized by altered bone quality and imbalanced bone remodeling, leading to skeletal fractures that are most prominent during childhood. Treatments for OI have focused on restoring pediatric bone density and architecture to recover functional strength and consequently reduce fragility. Though antiresorptive agents like bisphosphonates (BPs) are currently the most common intervention for the treatment of OI, a number of studies have shown efficacy of sclerostin antibody (SclAb) in inducing gains in bone mass and reducing fragility in OI mouse models. In this study, the effects of the concurrent use of BP and SclAb were evaluated during bone growth in a mouse harboring an OI‐causing Gly→Cys mutation on col1a1. A single dose of antiresorptive BP facilitated the anabolic action of SclAb by increasing availability of surfaces for new bone formation via retention of primary trabeculae that would otherwise be remodeled. Chronic effects of concurrent administration of BP and SclAb revealed that accumulating cycles conferred synergistic gains in trabecular mass and vertebral stiffness, suggesting a distinct advantage of both therapies combined. Cortical gains in mass and strength occurred through SclAb alone, independent of presence of BP. In conclusion, these preclinical results support the scientific hypothesis that minimal antiresorptive treatment can amplify the effects of SclAb during early stages of skeletal growth to further improve bone structure and rigidity, a beneficial outcome for children with OI. © 2018 American Society for Bone and Mineral Research.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144688/1/jbmr3421.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144688/2/jbmr3421_am.pd

    Developing evidence-informed, employer-led workplace health: Final report

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    What do we want to know? We sought to understand whether workplace health programmes (WHPs) are effective for improving health and business outcomes, and to identify the characteristics of WHPs that are thought to influence their success. To address these issues, we undertook a systematic review of three sources of evidence: systematic reviews examining intervention effectiveness; research on stakeholders’ views and experiences; and key workplace health policy documents. / What did we find? We identified 24 systematic reviews of WHPs which examined statistically the impact on a variety of outcomes, including mental health, weight management, absenteeism (and its costs), work ability and job stress. The reviews demonstrated that workplace health interventions are effective in improving health and business outcomes, and that the magnitude of effects on those outcomes is modest. Evidence from 10 views studies and 17 policy documents were integrated with evidence from systematic reviews to identify key characteristics of WHPs. Four characteristics were identified across each of the three evidence sources, suggesting that they could be implemented to good effect: financial commitment, ease of uptake, accessibility, and structures to promote social support. Five characteristics were identified in systematic reviews and views studies but have yet to be addressed by policy recommendations; these included the extent of policy integration, the importance of the implementer’s role within the company, the content of an intervention, whether the intervention is tailored or individualised, and issues related to acceptability. Four characteristics were identified as important in views studies or policy documents but had not been examined in systematic reviews, suggesting a need for future evaluation. These included managerial support, organisational support, channels of communication and the provision of tailored advice. The provider approach and the use of web-based technologies were identified in views research only. Each of these characteristics can be implemented in a variety of ways, suggesting creative possibilities for the ways in which businesses could integrate them into employer-led workplace health. / What are the conclusions? The findings suggest that employers can derive benefits from establishing WHPs, both for the business and with respect to their employees’ health. Interventions that are supported by organisational policy, focus their content on specific health issues and engage employees have been shown to be effective and are supported by stakeholder research and policy documents. Employers may find additional benefit if they also include specific characteristics related to the context in which a WHP intervention takes place, is implemented or is received by participants. The impacts of many WHP characteristics on health and business outcomes have yet to be evaluated and should be integrated into future WHP intervention evaluations. / How did we get these results? Comprehensive searching of electronic databases and websites was carried out to identify the three relevant datasets. Using framework synthesis, we combined evidence from the systematic reviews, views studies and policy documents by using a framework of characteristics potentially influencing workplace health effectiveness. Data analysis themes were then organised to produce tabular and narrative summaries of key characteristics of WHPs to produce an overall narrative

    Pamidronate Administration During Pregnancy and Lactation Induces Temporal Preservation of Maternal Bone Mass in a Mouse Model of Osteogenesis Imperfecta

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    During pregnancy and lactation, the maternal skeleton undergoes significant bone loss through increased resorption to provide the necessary calcium supply to the developing fetus and suckling neonate. This period of skeletal vulnerability has not been clearly associated with increased maternal fracture risk, but these physiological conditions can exacerbate an underlying metabolic bone condition like osteogenesis imperfecta. Although bisphosphonates (BPs) are commonly used in postmenopausal women, there are cases where premenopausal women taking BPs become pregnant. Given BPs’ long half‐life, there is a need to establish how BPs affect the maternal skeleton during periods of demanding metabolic bone changes that are critical for the skeletal development of their offspring. In the present study, pamidronate‐ (PAM‐) amplified pregnancy‐induced bone mass gains and lactation‐induced bone loss were prevented. This preservation of bone mass was less robust when PAM was administered at late stages of lactation compared with early pregnancy and first day of lactation. Pregnancy‐induced osteocyte osteolysis was also observed and was unaffected with PAM treatment. No negative skeletal effects were observed in offspring from PAM‐treated dams despite lactation‐induced bone loss prevention. These findings provide important insight into (1) a treatment window for when PAM is most effective in preserving maternal bone mass, and (2) the maternal changes in bone metabolism that maintain calcium homeostasis crucial for fetal and neonatal bone development. © 2019 American Society for Bone and Mineral ResearchPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153136/1/jbmr3831.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/153136/2/jbmr3831_am.pd

    Older and Younger Driver Performance at Complex Intersections: Implications for Using Perception-Response Time and Driving Simulation

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    Older drivers are at increased accident risk at intersections for a variety of maneuvers. To examine why, a study was conducted to assess older driver performance at complex intersections in a driving simulator. The University of Calgary Driving Simulator was used to test healthy older drivers (65-83, M = 71.4) and younger drivers (19-22, M = 20.7). Critical scenarios included the sudden appearance of a pedestrian in an intersection, a lastsecond yellow light, an unexpected change during a left, and a vehicle violating a stoplight. Older drivers had significantly higher perception response times (PRT) than younger drivers for the latter three of the four intersection scenarios. Analysis of specific maneuvers also revealed qualitative response differences between young and old groups. In contradiction to expectation, more older drivers ran the yellow light than younger drivers. The capability of older drivers to respond under time constraints is implicated. The utility of driving simulators to assess older driver performance at intersections was limited by the prevalence of simulator sickness

    Older and Younger Driver Performance at Complex Intersections: Implications for Using Perception-Response Time and Driving Simulation

    Get PDF
    Older drivers are at increased accident risk at intersections for a variety of maneuvers. To examine why, a study was conducted to assess older driver performance at complex intersections in a driving simulator. The University of Calgary Driving Simulator was used to test healthy older drivers (65-83, M = 71.4) and younger drivers (19-22, M = 20.7). Critical scenarios included the sudden appearance of a pedestrian in an intersection, a lastsecond yellow light, an unexpected change during a left, and a vehicle violating a stoplight. Older drivers had significantly higher perception response times (PRT) than younger drivers for the latter three of the four intersection scenarios. Analysis of specific maneuvers also revealed qualitative response differences between young and old groups. In contradiction to expectation, more older drivers ran the yellow light than younger drivers. The capability of older drivers to respond under time constraints is implicated. The utility of driving simulators to assess older driver performance at intersections was limited by the prevalence of simulator sickness

    Adults with Cerebral Palsy have Higher Prevalence of Fracture Compared with Adults Without Cerebral Palsy Independent of Osteoporosis and Cardiometabolic Diseases

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    Individuals with cerebral palsy (CP) have an increased risk of fracture throughout their lifespan based on an underdeveloped musculoskeletal system, excess body fat, diminished mechanical loading, and early development of noncommunicable diseases. However, the epidemiology of fracture among adults with CP is unknown. The purpose of this cross‐sectional study was to determine the prevalence of fracture among a large sample of privately insured adults with CP, as compared with adults without CP. Data were from the Optum Clinformatics Data Mart (Eden Prairie, MN, USA), a deidentified nationwide claims database of beneficiaries from a single private payer. Diagnostic codes were used to identify 18‐ to 64‐year‐old beneficiaries with and without CP and any fracture that consisted of osteoporotic pathological fracture as well as any type of fracture of the head/neck, thoracic, lumbar/pelvic, upper extremity, and lower extremity regions. The prevalence of any fracture was compared between adults with (n = 5,555) and without (n = 5.5 million) CP. Multivariable logistic regression was performed with all‐cause fracture as the outcome and CP group as the primary exposure. Adults with CP had a higher prevalence of all‐cause fracture (6.3% and 2.7%, respectively) and fracture of the head/neck, thoracic, lumbar/pelvic, upper extremity, and lower extremity regions compared with adults without CP (all p < 0.01). After adjusting for sociodemographic and socioeconomic variables, adults with CP had higher odds of all‐cause fracture compared with adults without CP (OR 2.5; 95% CI, 2.2 to 2.7). After further adjusting for cardiometabolic diseases, adults with CP had higher odds of all‐cause fracture compared with adults without CP (OR 2.2; 95% CI, 2.0 to 2.5). After further adjusting for osteoporosis, adults with CP still had higher odds of all‐cause fracture compared with adults without CP (OR 2.0; 95% CI, 1.8 to 2.2). These findings suggest that young and middle‐aged adults with CP have an elevated prevalence of all‐cause fracture compared with adults without CP, which was present even after accounting for cardiometabolic diseases and osteoporosis. © 2019 American Society for Bone and Mineral Research.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/150537/1/jbmr3694_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/150537/2/jbmr3694.pd
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